Product Data Sheet
AGF347
Catalog No. A31901
AGF347 is a potent multi-targeted antifolate that primarily inhibits serine hydroxymethyltransferase (SHMT)2 in mitochondria and SHMT1 in the cytosol, thereby disrupting de novo purine biosynthesis. This compound induces apoptosis, inhibits mTOR signaling, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS). AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates significant antitumor efficacy in SKOV3 EOC xenograft mouse models, making it a valuable tool for ovarian cancer research.
Chemical Information
| Catalog Num | A31901 |
|---|---|
| M. Wt | 473.45 |
| Formula | C22H24FN5O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2294820-23-6 |
| Synonyms | |
| SMILES | FC(C=C1CCCCN2C3=C(NC(N)=NC3=O)C=C2)=C(C=C1)C(N[C@H](C(O)=O)CCC(O)=O)=O |
Biological Activity
| Description | AGF347 is a potent multi-targeted antifolate that primarily inhibits serine hydroxymethyltransferase (SHMT)2 in mitochondria and SHMT1 in the cytosol, thereby disrupting de novo purine biosynthesis. This compound induces apoptosis, inhibits mTOR signaling, reduces glutathione (GSH) levels, and increases reactive oxygen species (ROS). AGF347 effectively inhibits the proliferation of both Cisplatin-sensitive and resistant epithelial ovarian cancer (EOC) cells and demonstrates significant antitumor efficacy in SKOV3 EOC xenograft mouse models, making it a valuable tool for ovarian cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
