Product Data Sheet
DNMT1-IN-5
Catalog No. A31935
DNMT1-IN-5 is a selective inhibitor targeting DNA methyltransferases DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. This compound demonstrates significant antiproliferative activity across various cancer cell lines, exhibiting IC50 values ranging from 0.19 to 2.37 μM in TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116. In addition to inducing cell cycle arrest at the G2/M phase, DNMT1-IN-5 promotes apoptosis in TMD-8 and DOHH2 cells and has shown antitumor efficacy in xenograft mouse models.
Chemical Information
| Catalog Num | A31935 |
|---|---|
| M. Wt | 437.56 |
| Formula | C24H32FN7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2982511-19-1 |
| Synonyms | |
| SMILES | CN1CCC(NC2=C3C(N(C=C3)CCCN4CCCC4)=NC(C5=CC=NC(F)=C5)=N2)CC1 |
Biological Activity
| Description | DNMT1-IN-5 is a selective inhibitor targeting DNA methyltransferases DNMT1 and DNMT3A, with IC50 values of 2.42 μM and 14.4 μM, respectively. This compound demonstrates significant antiproliferative activity across various cancer cell lines, exhibiting IC50 values ranging from 0.19 to 2.37 μM in TMD-8, DOHH2, MOLM-13, THP-1, RPIM-8226, and HCT116. In addition to inducing cell cycle arrest at the G2/M phase, DNMT1-IN-5 promotes apoptosis in TMD-8 and DOHH2 cells and has shown antitumor efficacy in xenograft mouse models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
