Product Data Sheet
APD-94
Catalog No. A31966
APD-94 is a dual inhibitor that targets both tubulin and Bmi-1, disrupting normal tubulin polymerization. This compound downregulates Bmi-1 expression, leading to cell cycle arrest at the G2/M phase and subsequent induction of apoptosis in cancer cells. APD-94 effectively inhibits cancer cell proliferation and demonstrates growth repression of HT29 cell xenografts in NOD/SCID mice. Its applications are particularly relevant in the study of colorectal cancer.
Chemical Information
| Catalog Num | A31966 |
|---|---|
| M. Wt | 339.35 |
| Formula | C18H17N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 877810-03-2 |
| Synonyms | |
| SMILES | COC1=CC(O)=C(C2=NC(N)=NC=C2OC3=CC(OC)=CC=C3)C=C1 |
Biological Activity
| Description | APD-94 is a dual inhibitor that targets both tubulin and Bmi-1, disrupting normal tubulin polymerization. This compound downregulates Bmi-1 expression, leading to cell cycle arrest at the G2/M phase and subsequent induction of apoptosis in cancer cells. APD-94 effectively inhibits cancer cell proliferation and demonstrates growth repression of HT29 cell xenografts in NOD/SCID mice. Its applications are particularly relevant in the study of colorectal cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
