Product Data Sheet
ICRF-196
Catalog No. A31988
ICRF-196 is a racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193, functioning as a potent inhibitor of DNA Topoisomerase II. This compound effectively inhibits DNA synthesis and promotes apoptosis, exhibiting significant anti-cancer and anti-inflammatory properties. Additionally, ICRF-196 demonstrates cardioprotective effects against anthracycline-induced toxicity in cardiomyocytes. It is applicable in research focusing on cancer, infectious diseases, inflammation, and cardiovascular disorders, including acute promyelocytic leukemia.
Chemical Information
| Catalog Num | A31988 |
|---|---|
| M. Wt | 282.30 |
| Formula | C12H18N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 21416-68-2 |
| Synonyms | |
| SMILES | CC(N(C1)CC(NC1=O)=O)C(N(C2)CC(NC2=O)=O)C |
Biological Activity
| Description | ICRF-196 is a racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193, functioning as a potent inhibitor of DNA Topoisomerase II. This compound effectively inhibits DNA synthesis and promotes apoptosis, exhibiting significant anti-cancer and anti-inflammatory properties. Additionally, ICRF-196 demonstrates cardioprotective effects against anthracycline-induced toxicity in cardiomyocytes. It is applicable in research focusing on cancer, infectious diseases, inflammation, and cardiovascular disorders, including acute promyelocytic leukemia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
