Product Data Sheet
Picropodophyllin-d3
Catalog No. A32011
Picropodophyllin-d3 is a deuterium-labeled derivative of Picropodophyllin, specifically characterized as an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, exhibiting an IC50 of 1 nM. This stable isotope is designed for use in metabolic studies and tracer experiments, providing enhanced sensitivity and precision in research applications. Its selective inhibition of IGF-1R makes it a valuable tool for investigating signaling pathways involved in cancer and metabolic disorders.
Chemical Information
| Catalog Num | A32011 |
|---|---|
| M. Wt | 417.42 |
| Formula | C22H19D3O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1454782-81-0 |
| Synonyms | AXL1717-d3; Picropodophyllotoxin-d3; PPP-d3 |
| SMILES | O=C1[C@@]2([H])[C@@](C3=CC(OC)=C(C(OC)=C3)OC([2H])([2H])[2H])([H])C4=CC(OCO5)=C5C=C4[C@@H]([C@@]2([H])CO1)O |
Biological Activity
| Description | Picropodophyllin-d3 is a deuterium-labeled derivative of Picropodophyllin, specifically characterized as an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, exhibiting an IC50 of 1 nM. This stable isotope is designed for use in metabolic studies and tracer experiments, providing enhanced sensitivity and precision in research applications. Its selective inhibition of IGF-1R makes it a valuable tool for investigating signaling pathways involved in cancer and metabolic disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
