Product Data Sheet
CIGB-552
Catalog No. A32041
CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers.
Chemical Information
| Catalog Num | A32041 |
|---|---|
| M. Wt | 2689.21 |
| Formula | C131H198N38O24 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1630763-23-3 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC=3C=4C(NC3)=CC=CC4)C(O)=O)=O)=O)CCCCN)=O)=O)CCCCN)=O)=O)CCCCN)=O)NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@@H](NC(=O)[C@@H]6N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC7=CN=CN7)NC(C)=O)=O)C)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)CCCCN)=O)CCC6)[C@@H](C)O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCCN)=O)C=8C=9C(NC8)=CC=CC9 |
Biological Activity
| Description | CIGB-552 is a cell-penetrating peptide that targets tumor cells to exert anti-cancer effects, demonstrating an IC50 of 23 μM in H460 lung cancer cells. This peptide enhances the expression of the protein COMMD1 and significantly inhibits the NF-κB signaling pathway, leading to increased apoptosis in tumor cells. Additionally, CIGB-552 induces the accumulation of reactive oxygen species (ROS) and exhibits both anti-inflammatory and anti-angiogenic properties. It is particularly relevant for research into lung and colon cancers. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
