Product Data Sheet
Gemcitabine triphosphate
Catalog No. A32048
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine, primarily targeting DNA replication pathways. It competes with cytidine triphosphate, effectively inhibiting chain elongation during DNA synthesis. With a Ki value of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε, Gemcitabine triphosphate disrupts both DNA and RNA synthesis, induces cell cycle arrest in G0/G1 and S phases, and promotes apoptosis. This compound is valuable for research applications in pancreatic cancer and non-small cell lung cancer.
Chemical Information
| Catalog Num | A32048 |
|---|---|
| M. Wt | 503.14 |
| Formula | C9H14F2N3O13P3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 110988-86-8 |
| Synonyms | dFdCTP |
| SMILES | NC(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)=NC1=O |
Biological Activity
| Description | Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine, primarily targeting DNA replication pathways. It competes with cytidine triphosphate, effectively inhibiting chain elongation during DNA synthesis. With a Ki value of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε, Gemcitabine triphosphate disrupts both DNA and RNA synthesis, induces cell cycle arrest in G0/G1 and S phases, and promotes apoptosis. This compound is valuable for research applications in pancreatic cancer and non-small cell lung cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
