Product Data Sheet
NOSH-aspirin
Catalog No. A32123
NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders.
Chemical Information
| Catalog Num | A32123 |
|---|---|
| M. Wt | 477.53 |
| Formula | C20H15NO7S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1357362-67-4 |
| Synonyms | NBS-1120 |
| SMILES | O=C(OC1=CC=C(C(SS2)=CC2=S)C=C1)C3=CC=CC=C3OC(CCCO[N+]([O-])=O)=O |
Biological Activity
| Description | NOSH-aspirin (NBS-1120) is a hybrid molecule designed to release both nitric oxide and hydrogen sulfide. This compound demonstrates potent inhibition of pancreatic cancer cell proliferation and induces apoptosis, making it a valuable tool in cancer research. Additionally, NOSH-aspirin has been shown to suppress NF-κB and FoxM1 activity in mouse models of pancreatic cancer. Its neuroprotective effects are evident in rat models of Parkinson's disease, where it alleviates motor deficits and reduces neuroinflammation associated with microglial and astrocytic activation. NOSH-aspirin is suitable for studies involving pancreatic cancer and neurodegenerative disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
