Product Data Sheet
PF-3758309 hydrochloride
Catalog No. A32125
PF-3758309 hydrochloride is a potent and reversible ATP-competitive inhibitor targeting PAK4, with a Kd of 2.7 nM and a Ki of 18.7 nM. This compound is effective in inhibiting anchorage-independent growth and inducing apoptosis, while also promoting cytoskeletal remodeling and suppressing cellular proliferation. PF-3758309 hydrochloride is valuable in research applications aimed at understanding PAK4's role in cancer and other diseases associated with dysregulated cell growth.
Chemical Information
| Catalog Num | A32125 |
|---|---|
| M. Wt | 527.08 |
| Formula | C25H31ClN8OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1279034-84-2 |
| Synonyms | PF-03758309 hydrochloride |
| SMILES | O=C(N1C(C)(C)C2=NNC(NC3=C4C(C=CS4)=NC(C)=N3)=C2C1)N[C@@H](C5=CC=CC=C5)CN(C)C.[H]Cl |
Biological Activity
| Description | PF-3758309 hydrochloride is a potent and reversible ATP-competitive inhibitor targeting PAK4, with a Kd of 2.7 nM and a Ki of 18.7 nM. This compound is effective in inhibiting anchorage-independent growth and inducing apoptosis, while also promoting cytoskeletal remodeling and suppressing cellular proliferation. PF-3758309 hydrochloride is valuable in research applications aimed at understanding PAK4's role in cancer and other diseases associated with dysregulated cell growth. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
