Product Data Sheet
MGD-22
Catalog No. A32192
MGD-22 is a molecular glue and an orally active degrader of the IKZF1/2/3 proteins, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. This compound exhibits significant anti-proliferative effects on various hematological cancer cell lines and induces apoptosis in these cells. Additionally, MGD-22 demonstrates robust anti-tumor efficacy in mouse models with NCI-H929 or WSU-DLCL-2 xenografts. It is a valuable tool for investigating hematological malignancies, particularly multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL).
Chemical Information
| Catalog Num | A32192 |
|---|---|
| M. Wt | 577.68 |
| Formula | C33H35N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2991818-12-1 |
| Synonyms | |
| SMILES | O=C(N1)C(N2N(CC3=C(C=CC=C3C2=O)NCC4=CC=C(CN5CCN(CC5)C6=CC=C(C=C6)C#N)C=C4)C)CCC1=O |
Biological Activity
| Description | MGD-22 is a molecular glue and an orally active degrader of the IKZF1/2/3 proteins, with DC50 values of 8.33 nM, 9.91 nM, and 5.74 nM, respectively. This compound exhibits significant anti-proliferative effects on various hematological cancer cell lines and induces apoptosis in these cells. Additionally, MGD-22 demonstrates robust anti-tumor efficacy in mouse models with NCI-H929 or WSU-DLCL-2 xenografts. It is a valuable tool for investigating hematological malignancies, particularly multiple myeloma (MM), acute myeloid leukemia (AML), and diffuse large B-cell lymphoma (DLBCL). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
