Product Data Sheet
Rilmenidine-d4
Catalog No. A32194
Rilmenidine-d4 is a deuterium-labeled derivative of Rilmenidine, a selective I1 imidazoline receptor agonist and antihypertensive agent. It exhibits key biological activities including the induction of autophagy and modulation of apoptosis through the pro-apoptotic protein Bax in human leukemic K562 cells. Rilmenidine also operates centrally to reduce sympathetic overactivity and affects renal function by inhibiting the Na+/H+ antiport. This stable isotope is valuable for pharmacokinetic studies and mechanistic investigations in cardiovascular and cancer research.
Chemical Information
| Catalog Num | A32194 |
|---|---|
| M. Wt | 184.27 |
| Formula | C10H12D4N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 85047-14-9 |
| Synonyms | |
| SMILES | [2H]C1([2H])C([2H])(OC(NC(C2CC2)C3CC3)=N1)[2H] |
Biological Activity
| Description | Rilmenidine-d4 is a deuterium-labeled derivative of Rilmenidine, a selective I1 imidazoline receptor agonist and antihypertensive agent. It exhibits key biological activities including the induction of autophagy and modulation of apoptosis through the pro-apoptotic protein Bax in human leukemic K562 cells. Rilmenidine also operates centrally to reduce sympathetic overactivity and affects renal function by inhibiting the Na+/H+ antiport. This stable isotope is valuable for pharmacokinetic studies and mechanistic investigations in cardiovascular and cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
