Product Data Sheet
MGF24
Catalog No. A32196
MGF24 is a protease-resistant derivative of mechanical growth factor (MGF) that primarily targets the neuroprotective pathway. It protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA)-induced apoptosis by inducing the expression of Heme oxygenase-1 (HO-1). MGF24 activates Protein Kinase C epsilon (PKC-ε) to stimulate Nrf2 activity, leading to enhanced HO-1 levels. This compound demonstrates significant neuroprotective effects and has potential applications in research related to neurological disorders such as stroke, nerve injury, and amyotrophic lateral sclerosis, as well as providing cardioprotective benefits in myocardial ischemia models.
Chemical Information
| Catalog Num | A32196 |
|---|---|
| M. Wt | 2848.09 |
| Formula | C121H195N41O39 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1611488-66-4 |
| Synonyms | |
| SMILES |
Biological Activity
| Description | MGF24 is a protease-resistant derivative of mechanical growth factor (MGF) that primarily targets the neuroprotective pathway. It protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA)-induced apoptosis by inducing the expression of Heme oxygenase-1 (HO-1). MGF24 activates Protein Kinase C epsilon (PKC-ε) to stimulate Nrf2 activity, leading to enhanced HO-1 levels. This compound demonstrates significant neuroprotective effects and has potential applications in research related to neurological disorders such as stroke, nerve injury, and amyotrophic lateral sclerosis, as well as providing cardioprotective benefits in myocardial ischemia models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
