Product Data Sheet
Tamoxifen-13C6
Catalog No. A32228
Tamoxifen-13C6 (ICI 47699-13C6) is a stable isotope-labeled variant of the selective estrogen receptor modulator (SERM), Tamoxifen (ICI 47699). This compound effectively blocks estrogen action in breast tissue while activating estrogenic pathways in other tissues such as bone, liver, and uterus. Additionally, it serves as a potent activator of the Hsp90 molecular chaperone, enhancing ATPase activity. Tamoxifen also demonstrates significant inhibitory effects against Ebola virus (EBOV Zaire) and Marburg virus (MARV) with IC50 values of 0.1 μM and 1.8 μM, respectively. Its biological activities include promoting autophagy, inducing apoptosis, and facilitating gene knockout in CreER transgenic mice, making it valuable for various research applications.
Chemical Information
| Catalog Num | A32228 |
|---|---|
| M. Wt | 377.47 |
| Formula | C2013C6H29NO |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1346606-38-9 |
| Synonyms | ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6 |
| SMILES | [H][13C]1=[13CH][13CH]=[13C](/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)[13CH]=[13CH]1 |
Biological Activity
| Description | Tamoxifen-13C6 (ICI 47699-13C6) is a stable isotope-labeled variant of the selective estrogen receptor modulator (SERM), Tamoxifen (ICI 47699). This compound effectively blocks estrogen action in breast tissue while activating estrogenic pathways in other tissues such as bone, liver, and uterus. Additionally, it serves as a potent activator of the Hsp90 molecular chaperone, enhancing ATPase activity. Tamoxifen also demonstrates significant inhibitory effects against Ebola virus (EBOV Zaire) and Marburg virus (MARV) with IC50 values of 0.1 μM and 1.8 μM, respectively. Its biological activities include promoting autophagy, inducing apoptosis, and facilitating gene knockout in CreER transgenic mice, making it valuable for various research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
