Product Data Sheet
Tubulin polymerization-IN-86
Catalog No. A32269
Tubulin polymerization-IN-86 is a potent inhibitor of tubulin polymerization that targets the colchicine binding sites on microtubulin, effectively disrupting the microtubule cytoskeleton. This compound demonstrates significant anti-proliferative activity against various cancer cell lines and induces mechanisms such as cell cycle arrest and apoptosis. Additionally, it inhibits cell migration and invasion, contributing to reduced long-term survival of cancer cells. Tubulin polymerization-IN-86 also exhibits efficacy in inhibiting tumor growth in murine models, making it a valuable tool for research in melanoma and related studies.
Chemical Information
| Catalog Num | A32269 |
|---|---|
| M. Wt | 372.37 |
| Formula | C20H20O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3105435-06-8 |
| Synonyms | |
| SMILES | COC(C(OC)=C(C=C1C/2=O)OC)=C1OCC2=C/C3=CC(OC)=C(O)C=C3 |
Biological Activity
| Description | Tubulin polymerization-IN-86 is a potent inhibitor of tubulin polymerization that targets the colchicine binding sites on microtubulin, effectively disrupting the microtubule cytoskeleton. This compound demonstrates significant anti-proliferative activity against various cancer cell lines and induces mechanisms such as cell cycle arrest and apoptosis. Additionally, it inhibits cell migration and invasion, contributing to reduced long-term survival of cancer cells. Tubulin polymerization-IN-86 also exhibits efficacy in inhibiting tumor growth in murine models, making it a valuable tool for research in melanoma and related studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
