Product Data Sheet
Atopaxar hydrochloride
Catalog No. A32289
Atopaxar hydrochloride is a selective and reversible antagonist of protease-activated receptor-1 (PAR-1) that functions primarily as a thrombin receptor inhibitor. This compound demonstrates significant biological activity by inhibiting Janus kinase 1 (JAK1) and JAK2, resulting in JAK-STAT pathway inhibition with an EC50 of 5.90 μM in A549 cells. It has been shown to decrease cell viability (IC50=7.02 μM), induce apoptosis, and arrest the cell cycle at the G1 phase. Atopaxar hydrochloride is valuable in research focused on atherothrombotic diseases and exhibits both antiplatelet and antitumor properties.
Chemical Information
| Catalog Num | A32289 |
|---|---|
| M. Wt | 564.09 |
| Formula | C29H39ClFN3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 474544-83-7 |
| Synonyms | E5555 hydrochloride; ER-172594-00 hydrochloride |
| SMILES | COC1=C(N2CCOCC2)C=C(C(CN(CC3=C4C(F)=C(OCC)C(OCC)=C3)C4=N)=O)C=C1C(C)(C)C.Cl |
Biological Activity
| Description | Atopaxar hydrochloride is a selective and reversible antagonist of protease-activated receptor-1 (PAR-1) that functions primarily as a thrombin receptor inhibitor. This compound demonstrates significant biological activity by inhibiting Janus kinase 1 (JAK1) and JAK2, resulting in JAK-STAT pathway inhibition with an EC50 of 5.90 μM in A549 cells. It has been shown to decrease cell viability (IC50=7.02 μM), induce apoptosis, and arrest the cell cycle at the G1 phase. Atopaxar hydrochloride is valuable in research focused on atherothrombotic diseases and exhibits both antiplatelet and antitumor properties. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
