Product Data Sheet
SKLB0565
Catalog No. A32306
SKLB0565 is a potent tubulin inhibitor that demonstrates significant anti-proliferative effects in colorectal carcinoma (CRC) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. This compound induces G2/M phase cell cycle arrest and triggers mitochondria-mediated intrinsic apoptosis. Additionally, SKLB0565 effectively inhibits cell migration and disrupts tube formation in human umbilical vein endothelial cells (HUVECs), making it a valuable tool for cancer research and the study of tumor angiogenesis.
Chemical Information
| Catalog Num | A32306 |
|---|---|
| M. Wt | 400.91 |
| Formula | C20H25ClN6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2414607-10-4 |
| Synonyms | |
| SMILES | O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1 |
Biological Activity
| Description | SKLB0565 is a potent tubulin inhibitor that demonstrates significant anti-proliferative effects in colorectal carcinoma (CRC) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. This compound induces G2/M phase cell cycle arrest and triggers mitochondria-mediated intrinsic apoptosis. Additionally, SKLB0565 effectively inhibits cell migration and disrupts tube formation in human umbilical vein endothelial cells (HUVECs), making it a valuable tool for cancer research and the study of tumor angiogenesis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
