Product Data Sheet
Microtubulin-IN-1
Catalog No. A32342
Microtubulin-IN-1 is a selective inhibitor of microtubulin that targets the colchicine-binding site, leading to disruption of microtubule integrity and upregulation of p53. It demonstrates significant antiproliferative activity across various cancer cell lines, with IC50 values of 2.4 nM for NCI-H460, 1.6 nM for BxPC-3, and 2.07 nM for HT-29. Microtubulin-IN-1 effectively induces cell cycle arrest at the G2/M phase and promotes apoptosis in NCI-H460 cells, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A32342 |
|---|---|
| M. Wt | 444.46 |
| Formula | C25H21FN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3025180-14-4 |
| Synonyms | |
| SMILES | FC1=CC=C(C(C2=CC=CC(/C=C3NC(/C(NC\3=O)=C/C4=NC=CN4C(C)C)=O)=C2)=O)C=C1 |
Biological Activity
| Description | Microtubulin-IN-1 is a selective inhibitor of microtubulin that targets the colchicine-binding site, leading to disruption of microtubule integrity and upregulation of p53. It demonstrates significant antiproliferative activity across various cancer cell lines, with IC50 values of 2.4 nM for NCI-H460, 1.6 nM for BxPC-3, and 2.07 nM for HT-29. Microtubulin-IN-1 effectively induces cell cycle arrest at the G2/M phase and promotes apoptosis in NCI-H460 cells, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
