Product Data Sheet
SKLB-C05
Catalog No. A32367
SKLB-C05 is a highly selective, orally active inhibitor of the T-Lymphokine-Activated Killer Cell-originated Protein Kinase (TOPK), exhibiting an IC50 of 0.5 nM. This compound has demonstrated the ability to induce apoptosis, downregulate c-Myc, and activate p53 while disrupting FAK/Src-mediated migratory signaling. Additionally, SKLB-C05 interferes with cell mitosis and displays significant anticancer activity specifically against TOPK-positive colorectal cancer, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A32367 |
|---|---|
| M. Wt | 394.89 |
| Formula | C23H23ClN2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2300981-68-2 |
| Synonyms | |
| SMILES | O=C1NC2=C(C)C=C(O)C(C3=CC=C(C=C3)[C@H](CN)C)=C2C4=C1C=CC=C4.Cl |
Biological Activity
| Description | SKLB-C05 is a highly selective, orally active inhibitor of the T-Lymphokine-Activated Killer Cell-originated Protein Kinase (TOPK), exhibiting an IC50 of 0.5 nM. This compound has demonstrated the ability to induce apoptosis, downregulate c-Myc, and activate p53 while disrupting FAK/Src-mediated migratory signaling. Additionally, SKLB-C05 interferes with cell mitosis and displays significant anticancer activity specifically against TOPK-positive colorectal cancer, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
