Product Data Sheet
Vandetanib-d4
Catalog No. A32438
Vandetanib-d4 is a deuterium-labeled derivative of Vandetanib, a potent orally active inhibitor targeting VEGFR2/KDR tyrosine kinase with an IC50 of 40 nM. In addition to its primary action, Vandetanib exhibits inhibitory effects on VEGFR3/FLT4 and EGFR/HER1 with IC50 values of 110 nM and 500 nM, respectively. This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and elucidating the pharmacological pathways of tyrosine kinase inhibitors.
Chemical Information
| Catalog Num | A32438 |
|---|---|
| M. Wt | 479.38 |
| Formula | C22H20D4BrFN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1215100-18-7 |
| Synonyms | |
| SMILES | N(C=1C2=C(C=C(OCC3CC(N(C)C(C3)([2H])[2H])([2H])[2H])C(OC)=C2)N=CN1)C4=C(F)C=C(Br)C=C4 |
Biological Activity
| Description | Vandetanib-d4 is a deuterium-labeled derivative of Vandetanib, a potent orally active inhibitor targeting VEGFR2/KDR tyrosine kinase with an IC50 of 40 nM. In addition to its primary action, Vandetanib exhibits inhibitory effects on VEGFR3/FLT4 and EGFR/HER1 with IC50 values of 110 nM and 500 nM, respectively. This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and elucidating the pharmacological pathways of tyrosine kinase inhibitors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
