Product Data Sheet
Thalidomide-4-O-CH2-COO(t-Bu)
Catalog No. A32447
Thalidomide-4-O-CH2-COO(t-Bu) is a modified form of Thalidomide that serves as a ligand for the E3 ligase Cereblon (CRBN). It effectively recruits CRBN proteins, facilitating profound biological activity associated with protein degradation pathways. The tert-butyl protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC molecules. This compound is essential for researchers working on CRBN-based PROTAC development.
Chemical Information
| Catalog Num | A32447 |
|---|---|
| M. Wt | 388.37 |
| Formula | C19H20N2O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1950635-36-5 |
| Synonyms | |
| SMILES | O=C1N(C2C(NC(CC2)=O)=O)C(C3=C1C(OCC(OC(C)(C)C)=O)=CC=C3)=O |
Biological Activity
| Description | Thalidomide-4-O-CH2-COO(t-Bu) is a modified form of Thalidomide that serves as a ligand for the E3 ligase Cereblon (CRBN). It effectively recruits CRBN proteins, facilitating profound biological activity associated with protein degradation pathways. The tert-butyl protecting group can be removed under acidic conditions, enabling its use in the synthesis of PROTAC molecules. This compound is essential for researchers working on CRBN-based PROTAC development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
