Product Data Sheet
Momelotinib-d4 dihydrochloride hydrate
Catalog No. A32468
Momelotinib-d4 dihydrochloride hydrate is a deuterium-labeled derivative of Momelotinib, an ATP-competitive inhibitor of Janus kinases JAK1 and JAK2, exhibiting IC50 values of 11 nM and 18 nM, respectively. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for the elucidation of drug metabolism and biodistribution in various biological systems. Additionally, its limited activity against JAK3 makes it a valuable tool for selective JAK inhibition studies.
Chemical Information
| Catalog Num | A32468 |
|---|---|
| M. Wt | 509.42 |
| Formula | C23H22D4Cl2N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2056097-81-3 |
| Synonyms | CYT387-d4 hydrochloride hydrate |
| SMILES | N#CCNC(C(C=C1)=CC=C1C2=NC(NC3=CC=C(N4C([2H])([2H])COCC4([2H])[2H])C=C3)=NC=C2)=O.Cl.O.Cl |
Biological Activity
| Description | Momelotinib-d4 dihydrochloride hydrate is a deuterium-labeled derivative of Momelotinib, an ATP-competitive inhibitor of Janus kinases JAK1 and JAK2, exhibiting IC50 values of 11 nM and 18 nM, respectively. This stable isotope-labeled compound is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for the elucidation of drug metabolism and biodistribution in various biological systems. Additionally, its limited activity against JAK3 makes it a valuable tool for selective JAK inhibition studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
