Product Data Sheet
Licofelone-d6
Catalog No. A32542
Licofelone-d6 is a deuterium-labeled derivative of Licofelone, a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 0.21 µM and 0.18 µM, respectively. This compound demonstrates significant anti-inflammatory and anti-proliferative properties, making it relevant for research in osteoarthritis treatments. Licofelone-induced apoptosis and its ability to reduce the production of proinflammatory leukotrienes and prostaglandins further underscore its potential as a valuable tool in chemical biology.
Chemical Information
| Catalog Num | A32542 |
|---|---|
| M. Wt | 385.92 |
| Formula | C23H16D6ClNO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1178549-81-9 |
| Synonyms | ML-3000-d6 |
| SMILES | OC(CC1=C(C2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C4N1CC(C([2H])([2H])[2H])(C4)C([2H])([2H])[2H])=O |
Biological Activity
| Description | Licofelone-d6 is a deuterium-labeled derivative of Licofelone, a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 0.21 µM and 0.18 µM, respectively. This compound demonstrates significant anti-inflammatory and anti-proliferative properties, making it relevant for research in osteoarthritis treatments. Licofelone-induced apoptosis and its ability to reduce the production of proinflammatory leukotrienes and prostaglandins further underscore its potential as a valuable tool in chemical biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
