Product Data Sheet
BNN27
Catalog No. A32547
BNN27 is a selective agonist of the TrkA and p75NTR receptors, demonstrating significant neurotrophic and anti-apoptotic activity. This compound enhances the levels of key neurotransmitters, including glutamate, GABA, and glutamine, in rat hippocampal and prefrontal cortical tissues, thereby improving glutamate turnover. BNN27 has shown neuroprotective effects in a mouse model of amyotrophic lateral sclerosis (ALS), anti-inflammatory properties in experimental autoimmune encephalomyelitis (EAE), and retinal protective efficacy in diabetic rat models. Additionally, BNN27 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research.
Chemical Information
| Catalog Num | A32547 |
|---|---|
| M. Wt | 332.48 |
| Formula | C21H32O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1195795-81-3 |
| Synonyms | |
| SMILES | C[C@@]12[C@]3(CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC2)[C@H](O3)CO |
Biological Activity
| Description | BNN27 is a selective agonist of the TrkA and p75NTR receptors, demonstrating significant neurotrophic and anti-apoptotic activity. This compound enhances the levels of key neurotransmitters, including glutamate, GABA, and glutamine, in rat hippocampal and prefrontal cortical tissues, thereby improving glutamate turnover. BNN27 has shown neuroprotective effects in a mouse model of amyotrophic lateral sclerosis (ALS), anti-inflammatory properties in experimental autoimmune encephalomyelitis (EAE), and retinal protective efficacy in diabetic rat models. Additionally, BNN27 is capable of crossing the blood-brain barrier, making it a valuable tool for neurological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
