Product Data Sheet
JND4135
Catalog No. A32570
JND4135 is a Type II TRK inhibitor that effectively targets TRKA, TRKB, and TRKC with IC50 values of 2.79, 3.19, and 3.01 nM, respectively. This compound is capable of overcoming resistance associated with TRK xDFG and other mutant forms, inhibiting the phosphorylation of both wild-type and mutant TRKs, as well as their downstream signaling pathways. JND4135 induces G0/G1 phase cell cycle arrest and apoptosis in BaF3–CD74-TRKA-G667C cells and exhibits potent antitumor activity in a BaF3-CD74-TRKA-G667C mouse xenograft model, highlighting its potential for cancer research and therapy.
Chemical Information
| Catalog Num | A32570 |
|---|---|
| M. Wt | 597.75 |
| Formula | C37H39N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2366216-76-2 |
| Synonyms | |
| SMILES | CC1=C(C(NC2=CC(CN3CCN(C)CC3)=CC(C(C)C)=C2)=O)C=CC=C1C#CC4=CN=C5N4C=C(C6=CC=C(N)C=C6)N=C5 |
Biological Activity
| Description | JND4135 is a Type II TRK inhibitor that effectively targets TRKA, TRKB, and TRKC with IC50 values of 2.79, 3.19, and 3.01 nM, respectively. This compound is capable of overcoming resistance associated with TRK xDFG and other mutant forms, inhibiting the phosphorylation of both wild-type and mutant TRKs, as well as their downstream signaling pathways. JND4135 induces G0/G1 phase cell cycle arrest and apoptosis in BaF3–CD74-TRKA-G667C cells and exhibits potent antitumor activity in a BaF3-CD74-TRKA-G667C mouse xenograft model, highlighting its potential for cancer research and therapy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
