Product Data Sheet
Angiogenesis inhibitor 2
Catalog No. A32652
Angiogenesis Inhibitor 2 is a potent inhibitor of angiogenesis, primarily targeting endothelial cell proliferation. This compound effectively inhibits the growth of human umbilical vein endothelial cells (HUVEC) and HCT-15 colorectal cancer cells, exhibiting IC50 values of 1.93 μM and 0.21 μM, respectively. Additionally, Angiogenesis Inhibitor 2 induces apoptosis in these cell lines and demonstrates significant anticancer properties by suppressing cancer cell invasion. Its efficacy is further illustrated in in vivo models, where it inhibits angiogenesis in zebrafish embryos, making it a valuable tool in cancer research and drug development.
Chemical Information
| Catalog Num | A32652 |
|---|---|
| M. Wt | 738.93 |
| Formula | C42H50N4O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2151067-32-0 |
| Synonyms | |
| SMILES | COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=C(C=C(C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)OC)NC(NC(C)C)=S |
Biological Activity
| Description | Angiogenesis Inhibitor 2 is a potent inhibitor of angiogenesis, primarily targeting endothelial cell proliferation. This compound effectively inhibits the growth of human umbilical vein endothelial cells (HUVEC) and HCT-15 colorectal cancer cells, exhibiting IC50 values of 1.93 μM and 0.21 μM, respectively. Additionally, Angiogenesis Inhibitor 2 induces apoptosis in these cell lines and demonstrates significant anticancer properties by suppressing cancer cell invasion. Its efficacy is further illustrated in in vivo models, where it inhibits angiogenesis in zebrafish embryos, making it a valuable tool in cancer research and drug development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
