Product Data Sheet
ZINC13000658
Catalog No. A32675
ZINC13000658 is an inhibitor of METTL, a family of methyltransferases. This compound demonstrates substantial antiproliferative effects across various cell lines, effectively inducing G1 phase cell cycle arrest and apoptosis in HepG2 (IC50 = 5.632 µM) and SNU-449 (IC50 = 6.184 µM) cells. ZINC13000658's mechanism may involve the inhibition of multiple methyltransferases, including METTL1, METTL3, METTL6, METTL16, and METTL18. This reagent is valuable for investigating various cancer research applications.
Chemical Information
| Catalog Num | A32675 |
|---|---|
| M. Wt | 361.39 |
| Formula | C21H19N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1324070-76-9 |
| Synonyms | |
| SMILES | COC1=CC=C2C(C=CN2CCNC(C3=CC(NC4=CC=CC=C43)=O)=O)=C1 |
Biological Activity
| Description | ZINC13000658 is an inhibitor of METTL, a family of methyltransferases. This compound demonstrates substantial antiproliferative effects across various cell lines, effectively inducing G1 phase cell cycle arrest and apoptosis in HepG2 (IC50 = 5.632 µM) and SNU-449 (IC50 = 6.184 µM) cells. ZINC13000658's mechanism may involve the inhibition of multiple methyltransferases, including METTL1, METTL3, METTL6, METTL16, and METTL18. This reagent is valuable for investigating various cancer research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
