Product Data Sheet
SGI-1776
Catalog No. A32740
SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network.
Chemical Information
| Catalog Num | A32740 |
|---|---|
| M. Wt | 601.57 |
| Formula | C20H26F3N5O9S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1173928-26-1 |
| Synonyms | |
| SMILES | CN1CCC(CC1)CNC2=NN3C(C=C2)=NC=C3C4=CC=CC(OC(F)(F)F)=C4.O=S(O)(O)=O.O=S(O)(O)=O |
Biological Activity
| Description | SGI-1776 is a selective inhibitor of Pim kinases, exhibiting IC50 values of 7 nM for Pim-1, 363 nM for Pim-2, and 69 nM for Pim-3. This compound has been identified as an autophagy inducer, showcasing potential mechanisms in cellular pathways associated with cancer and metabolic disorders. SGI-1776 is employed in research applications focusing on the modulation of cell survival and proliferation, making it a valuable tool for investigating therapeutic strategies targeting the Pim kinase signaling network. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
