Product Data Sheet
GEM-5
Catalog No. A32790
GEM-5 is a gemcitabine-based conjugate that functions as a potent HIF-1α inhibitor, with an IC50 value of 30 nM. This compound effectively down-regulates HIF-1α expression while promoting the up-regulation of the tumor suppressor protein p53. GEM-5 has demonstrated the ability to induce apoptosis in A2780 cancer cells and inhibit tumor growth, making it a valuable tool for cancer research and therapeutic studies targeting hypoxia-driven tumor progression.
Chemical Information
| Catalog Num | A32790 |
|---|---|
| M. Wt | 649.60 |
| Formula | C32H29F2N5O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2233543-49-0 |
| Synonyms | |
| SMILES | NC(C=CN1[C@@H]2O[C@@H]([C@H](C2(F)F)O)COC(CCC(OCC3=CC=C(O3)C4=NN(C5=C4C=CC=C5)CC6=CC=CC=C6)=O)=O)=NC1=O |
Biological Activity
| Description | GEM-5 is a gemcitabine-based conjugate that functions as a potent HIF-1α inhibitor, with an IC50 value of 30 nM. This compound effectively down-regulates HIF-1α expression while promoting the up-regulation of the tumor suppressor protein p53. GEM-5 has demonstrated the ability to induce apoptosis in A2780 cancer cells and inhibit tumor growth, making it a valuable tool for cancer research and therapeutic studies targeting hypoxia-driven tumor progression. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
