Product Data Sheet
Dapivirine-d11
Catalog No. A32810
Dapivirine-d11 is a deuterium-labeled derivative of Dapivirine, a nonnucleoside reverse transcriptase inhibitor (NRTI) that specifically targets HIV-1 reverse transcriptase. This stable isotope-labeled compound is utilized in research to investigate the metabolic pathways and pharmacokinetics of Dapivirine. Additionally, Dapivirine has been shown to modulate autophagy and activate key signaling molecules such as Akt, Bad, and SAPK/JNK, making it relevant for studies in HIV therapy and cellular response mechanisms.
Chemical Information
| Catalog Num | A32810 |
|---|---|
| M. Wt | 340.47 |
| Formula | C20H8D11N5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1329613-10-6 |
| Synonyms | TMC120-d11; R147681-d11 |
| SMILES | N#CC1=CC=C(NC2=NC=CC(NC3=C(C([2H])([2H])[2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C3C([2H])([2H])[2H])=N2)C=C1 |
Biological Activity
| Description | Dapivirine-d11 is a deuterium-labeled derivative of Dapivirine, a nonnucleoside reverse transcriptase inhibitor (NRTI) that specifically targets HIV-1 reverse transcriptase. This stable isotope-labeled compound is utilized in research to investigate the metabolic pathways and pharmacokinetics of Dapivirine. Additionally, Dapivirine has been shown to modulate autophagy and activate key signaling molecules such as Akt, Bad, and SAPK/JNK, making it relevant for studies in HIV therapy and cellular response mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
