Product Data Sheet
MDM2/4-p53-IN-2
Catalog No. A32843
MDM2/4-p53-IN-2 is a potent dual inhibitor of MDM2 and MDM4, functioning as an activator of p53. With IC50 values of 70.7 nM and 81.4 nM for the MDM2-p53 and MDM4-p53 complexes, respectively, this compound effectively regulates the cell cycle and induces apoptosis. It demonstrates significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the modulation of p53 signaling pathways.
Chemical Information
| Catalog Num | A32843 |
|---|---|
| M. Wt | 532.78 |
| Formula | C25H17Cl3FN3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3037300-49-2 |
| Synonyms | |
| SMILES | O=C(OCC)C([C@@H]1C2=CC=CC(Cl)=C2F)=NN([C@]13C(NC4=C3C=CC(Cl)=C4)=O)C5=CC=C(C=C5)Cl |
Biological Activity
| Description | MDM2/4-p53-IN-2 is a potent dual inhibitor of MDM2 and MDM4, functioning as an activator of p53. With IC50 values of 70.7 nM and 81.4 nM for the MDM2-p53 and MDM4-p53 complexes, respectively, this compound effectively regulates the cell cycle and induces apoptosis. It demonstrates significant anticancer activity, making it a valuable tool for research focused on cancer therapeutics and the modulation of p53 signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
