Product Data Sheet
ZMF-10
Catalog No. A32852
ZMF-10 is a potent PAK1 inhibitor, exhibiting an IC50 of 174 nM for PAK1 and varying potencies for related isoforms PAK2 and PAK3 at 1.038 µM and 1.372 µM, respectively. This compound effectively inhibits PAK1 activity, influencing PAK1-regulated processes such as apoptosis, ER stress response, and cellular migration in MDA-MB-231 breast cancer cells. ZMF-10 is suitable for investigations into mechanisms of anticancer therapy and related cellular pathways.
Chemical Information
| Catalog Num | A32852 |
|---|---|
| M. Wt | 473.37 |
| Formula | C19H17F6N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2415295-37-1 |
| Synonyms | |
| SMILES | O=C(NC1CCN(CC1)C2=C3C=NNC3=NC=N2)NC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4 |
Biological Activity
| Description | ZMF-10 is a potent PAK1 inhibitor, exhibiting an IC50 of 174 nM for PAK1 and varying potencies for related isoforms PAK2 and PAK3 at 1.038 µM and 1.372 µM, respectively. This compound effectively inhibits PAK1 activity, influencing PAK1-regulated processes such as apoptosis, ER stress response, and cellular migration in MDA-MB-231 breast cancer cells. ZMF-10 is suitable for investigations into mechanisms of anticancer therapy and related cellular pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
