Product Data Sheet
Mitotane-13C12
Catalog No. A32875
Mitotane-13C12 (2,4′-DDD-13C12) is a stable isotope-labeled form of Mitotane, an antineoplastic agent primarily utilized in the study of adrenocortical carcinoma. This compound exerts its adrenocorticolytic effects through mechanisms involving lipotoxicity and the accumulation of intracellular free cholesterol. Additionally, Mitotane influences endocrine functions by affecting corticotroph cells in the pituitary and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This reagent is valuable for metabolic and pharmacokinetic studies in cancer research.
Chemical Information
| Catalog Num | A32875 |
|---|---|
| M. Wt | 331.95 |
| Formula | C213C12H10Cl4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2483736-36-1 |
| Synonyms | 2,4′-DDD-13C12; o,p'-DDD-13C12 |
| SMILES | ClC(Cl)C([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)Cl)[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)Cl |
Biological Activity
| Description | Mitotane-13C12 (2,4′-DDD-13C12) is a stable isotope-labeled form of Mitotane, an antineoplastic agent primarily utilized in the study of adrenocortical carcinoma. This compound exerts its adrenocorticolytic effects through mechanisms involving lipotoxicity and the accumulation of intracellular free cholesterol. Additionally, Mitotane influences endocrine functions by affecting corticotroph cells in the pituitary and induces CYP3A4 gene expression via activation of the steroid and xenobiotic receptor (SXR). This reagent is valuable for metabolic and pharmacokinetic studies in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
