Product Data Sheet
Metformin-d6
Catalog No. A32886
Metformin-d6 (1,1-Dimethylbiguanide-d6) serves as a stable isotope-labeled version of Metformin, which primarily targets the mitochondrial respiratory chain in the liver. This compound is critical for studies on type 2 diabetes management due to its role in activating AMPK, thus enhancing insulin sensitivity. Additionally, Metformin-d6 contributes to understanding glucose regulation through the inhibition of Rap1 in SF1 hypothalamic neurons. Its utility extends to investigating liver oxidative stress and the modulation of autophagy-related proteins via AMPK activation and mTOR inhibition, making it relevant for evaluating renal cell carcinoma growth in both in vitro and in vivo settings.
Chemical Information
| Catalog Num | A32886 |
|---|---|
| M. Wt | 135.20 |
| Formula | C4H5D6N5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1185512-92-8 |
| Synonyms | 1,1-Dimethylbiguanide-d6 |
| SMILES | N=C(N)NC(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=N |
Biological Activity
| Description | Metformin-d6 (1,1-Dimethylbiguanide-d6) serves as a stable isotope-labeled version of Metformin, which primarily targets the mitochondrial respiratory chain in the liver. This compound is critical for studies on type 2 diabetes management due to its role in activating AMPK, thus enhancing insulin sensitivity. Additionally, Metformin-d6 contributes to understanding glucose regulation through the inhibition of Rap1 in SF1 hypothalamic neurons. Its utility extends to investigating liver oxidative stress and the modulation of autophagy-related proteins via AMPK activation and mTOR inhibition, making it relevant for evaluating renal cell carcinoma growth in both in vitro and in vivo settings. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
