Product Data Sheet
TrxR1-IN-B19
Catalog No. A33007
TrxR1-IN-B19 is a covalent inhibitor of the enzyme thioredoxin reductase 1 (TrxR1). By inhibiting TrxR1 activity, it elevates oxidative stress, which triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and mitochondrial dysfunction. This cascade of events ultimately leads to cell cycle arrest and apoptosis, making TrxR1-IN-B19 a valuable tool for investigating apoptotic pathways in cellular models of disease.
Chemical Information
| Catalog Num | A33007 |
|---|---|
| M. Wt | 354.40 |
| Formula | C21H22O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 170950-29-5 |
| Synonyms | GO-Y015 |
| SMILES | COC(C(OC)=CC=C1)=C1/C=C/C(/C=C/C2=C(C(OC)=CC=C2)OC)=O |
Biological Activity
| Description | TrxR1-IN-B19 is a covalent inhibitor of the enzyme thioredoxin reductase 1 (TrxR1). By inhibiting TrxR1 activity, it elevates oxidative stress, which triggers reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress and mitochondrial dysfunction. This cascade of events ultimately leads to cell cycle arrest and apoptosis, making TrxR1-IN-B19 a valuable tool for investigating apoptotic pathways in cellular models of disease. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
