Product Data Sheet
Lenalidomide-d4
Catalog No. A33043
Lenalidomide-d4 is a deuterium-labeled derivative of Lenalidomide, functioning as a stable isotope for advanced chemical research. As an orally active immunomodulator, Lenalidomide targets the cereblon (CRBN) ubiquitin E3 ligase, leading to the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3. This activity is particularly relevant in the context of mature B-cell lymphomas, including multiple myeloma, where Lenalidomide-d4 has been shown to inhibit tumor growth and promote IL-2 release from T cells. This reagent is suitable for studies in drug mechanisms and development within the field of oncology.
Chemical Information
| Catalog Num | A33043 |
|---|---|
| M. Wt | 263.29 |
| Formula | C13H9D4N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1130061-52-7 |
| Synonyms | CC-5013-d4 |
| SMILES | O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)CC3=C(N)C=CC=C31 |
Biological Activity
| Description | Lenalidomide-d4 is a deuterium-labeled derivative of Lenalidomide, functioning as a stable isotope for advanced chemical research. As an orally active immunomodulator, Lenalidomide targets the cereblon (CRBN) ubiquitin E3 ligase, leading to the selective ubiquitination and degradation of transcription factors IKZF1 and IKZF3. This activity is particularly relevant in the context of mature B-cell lymphomas, including multiple myeloma, where Lenalidomide-d4 has been shown to inhibit tumor growth and promote IL-2 release from T cells. This reagent is suitable for studies in drug mechanisms and development within the field of oncology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
