Product Data Sheet
Complex 3
Catalog No. A33085
Complex 3 is a fluorescent dithiocarbazate-copper complex targeting mitochondrial function, demonstrating significant anticancer properties. It exhibits excitation and emission maxima of 455-495 nm and 535 nm, respectively. Complex 3 effectively inhibits the proliferation of several pancreatic cancer cell lines, including BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Additionally, it induces lipid peroxidation, mitochondrial rupture, and apoptosis, while also disrupting cytokine-cytokine receptor interactions in AsPC-1 cells. In vivo, Complex 3 has demonstrated efficacy by reducing tumor volume in an AsPC-1 mouse xenograft model, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A33085 |
|---|---|
| M. Wt | 1005.12 |
| Formula | C26H22Br3Cu3N8S4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2480150-28-3 |
| Synonyms | |
| SMILES | [Br-][Cu+2]1([S-]2)[N](N=C2SC)=C(C3=CC=CC=[N]3[Cu+]([N]4=CC=CC=C4C(C5=CC=CC=[N]56)=[N](N=C7SC)[Cu+2]6([S-]7)[Br-])[Br-])C8=CC=CC=[N]81 |
Biological Activity
| Description | Complex 3 is a fluorescent dithiocarbazate-copper complex targeting mitochondrial function, demonstrating significant anticancer properties. It exhibits excitation and emission maxima of 455-495 nm and 535 nm, respectively. Complex 3 effectively inhibits the proliferation of several pancreatic cancer cell lines, including BxPC-3, AsPC-1, PANC-1, and WI38, with IC50 values of 0.74, 0.41, 0.62, and 2.06 µM, respectively. Additionally, it induces lipid peroxidation, mitochondrial rupture, and apoptosis, while also disrupting cytokine-cytokine receptor interactions in AsPC-1 cells. In vivo, Complex 3 has demonstrated efficacy by reducing tumor volume in an AsPC-1 mouse xenograft model, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
