Product Data Sheet
TDP-665759
Catalog No. A33151
TDP-665759 is a p53 activator that functions by inhibiting the HDM2:p53 complex, thereby promoting p53 activity. It exhibits significant inhibition of the STAT3 signaling pathway with an EC50 of 5.90 μM and reduces cell viability in p53-expressing A549R cells, demonstrating an IC50 of 7.02 μM. TDP-665759 has also been shown to induce apoptosis in HepG2 cells and displays antitumor efficacy in mouse models, making it a valuable tool for cancer research and therapeutic development.
Chemical Information
| Catalog Num | A33151 |
|---|---|
| M. Wt | 706.44 |
| Formula | C31H34Cl2IN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 787632-66-0 |
| Synonyms | |
| SMILES | O=C([C@H](C1=CC=C(Cl)C=C1)N2[C@@H](C3=CC=C(Cl)C=C3N)C)N(CCCN4CCN(C)CC4)C5=CC=C(I)C=C5C2=O |
Biological Activity
| Description | TDP-665759 is a p53 activator that functions by inhibiting the HDM2:p53 complex, thereby promoting p53 activity. It exhibits significant inhibition of the STAT3 signaling pathway with an EC50 of 5.90 μM and reduces cell viability in p53-expressing A549R cells, demonstrating an IC50 of 7.02 μM. TDP-665759 has also been shown to induce apoptosis in HepG2 cells and displays antitumor efficacy in mouse models, making it a valuable tool for cancer research and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
