Product Data Sheet
Fosmanogepix
Catalog No. A33183
Fosmanogepix is a novel antifungal agent that selectively inhibits the Gwt1 enzyme, essential for the proper localization of glycosylphosphatidylinositol-anchored mannoproteins in fungal cells. By disrupting the localization of these critical cell wall components, Fosmanogepix compromises fungal cell wall integrity, inhibits biofilm formation, and impedes germ tube morphogenesis, ultimately curtailing fungal growth. This compound is primarily utilized in research focused on invasive fungal infections, offering valuable insights into therapeutic strategies.
Chemical Information
| Catalog Num | A33183 |
|---|---|
| M. Wt | 468.40 |
| Formula | C22H21N4O6P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2091769-17-2 |
| Synonyms | APX001; E1211 |
| SMILES | O=P(OC[N+]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O-] |
Biological Activity
| Description | Fosmanogepix is a novel antifungal agent that selectively inhibits the Gwt1 enzyme, essential for the proper localization of glycosylphosphatidylinositol-anchored mannoproteins in fungal cells. By disrupting the localization of these critical cell wall components, Fosmanogepix compromises fungal cell wall integrity, inhibits biofilm formation, and impedes germ tube morphogenesis, ultimately curtailing fungal growth. This compound is primarily utilized in research focused on invasive fungal infections, offering valuable insights into therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
