Product Data Sheet
JAK1-IN-11
Catalog No. A33264
JAK1-IN-11 is a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 0.02 nM, demonstrating strong potency. It also exhibits inhibitory activity against JAK2 with an IC50 of 0.44 nM. Due to its high selectivity for JAK1, JAK1-IN-11 is an essential tool for investigating JAK-dependent signaling pathways and exploring therapeutic strategies in various inflammatory and autoimmune diseases.
Chemical Information
| Catalog Num | A33264 |
|---|---|
| M. Wt | 528.67 |
| Formula | C26H36N6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2427608-43-1 |
| Synonyms | |
| SMILES | C[C@@H](O)C1=NC2=CNC3=NC=CC3=C2N1N(CC4)CCC4CNS(C[C@@]56C(C)(C)[C@@](CC6)([H])CC5=O)(=O)=O |
Biological Activity
| Description | JAK1-IN-11 is a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 0.02 nM, demonstrating strong potency. It also exhibits inhibitory activity against JAK2 with an IC50 of 0.44 nM. Due to its high selectivity for JAK1, JAK1-IN-11 is an essential tool for investigating JAK-dependent signaling pathways and exploring therapeutic strategies in various inflammatory and autoimmune diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
