Product Data Sheet
Pacritinib citrate
Catalog No. A33269
Pacritinib citrate is a selective inhibitor of Janus kinase 2 (JAK2), effective against both wild-type JAK2 (IC50 = 23 nM) and the JAK2V617F mutant (IC50 = 19 nM). In addition to its primary target, Pacritinib citrate also inhibits FLT3 and its mutant FLT3D835Y (IC50 = 22 nM and 6 nM, respectively). This compound is relevant for research focused on acute myeloid leukemia (AML) and myelofibrosis (MF), providing a valuable tool for elucidating the role of JAK2 and FLT3 in these hematological malignancies.
Chemical Information
| Catalog Num | A33269 |
|---|---|
| M. Wt | 664.70 |
| Formula | C34H40N4O10 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1228923-42-9 |
| Synonyms | SB1518 citrate |
| SMILES | OC(CC(CC(O)=O)(C(O)=O)O)=O.C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1 |
Biological Activity
| Description | Pacritinib citrate is a selective inhibitor of Janus kinase 2 (JAK2), effective against both wild-type JAK2 (IC50 = 23 nM) and the JAK2V617F mutant (IC50 = 19 nM). In addition to its primary target, Pacritinib citrate also inhibits FLT3 and its mutant FLT3D835Y (IC50 = 22 nM and 6 nM, respectively). This compound is relevant for research focused on acute myeloid leukemia (AML) and myelofibrosis (MF), providing a valuable tool for elucidating the role of JAK2 and FLT3 in these hematological malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
