Product Data Sheet
Ritlecitinib tosylate
Catalog No. A33270
Ritlecitinib tosylate is a selective, orally active, irreversible covalent inhibitor of JAK3, exhibiting an IC50 value of 33 nM. It does not inhibit JAK1, JAK2, or TYK2, demonstrating a unique specificity for JAK3. This compound effectively interrupts signaling and downstream STAT phosphorylation induced by common gamma chain cytokines like IL-2 and IL-15. Ritlecitinib tosylate has been shown to inhibit Th1/Th17 cell differentiation and function, making it a valuable tool for research applications related to autoimmune diseases, with demonstrated efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
Chemical Information
| Catalog Num | A33270 |
|---|---|
| M. Wt | 457.55 |
| Formula | C22H27N5O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2192215-81-7 |
| Synonyms | PF-06651600 tosylate |
| SMILES | CC(C=C1)=CC=C1S(O)(=O)=O.C=CC(N2[C@@H](C)CC[C@@H](NC3=C4C(NC=C4)=NC=N3)C2)=O |
Biological Activity
| Description | Ritlecitinib tosylate is a selective, orally active, irreversible covalent inhibitor of JAK3, exhibiting an IC50 value of 33 nM. It does not inhibit JAK1, JAK2, or TYK2, demonstrating a unique specificity for JAK3. This compound effectively interrupts signaling and downstream STAT phosphorylation induced by common gamma chain cytokines like IL-2 and IL-15. Ritlecitinib tosylate has been shown to inhibit Th1/Th17 cell differentiation and function, making it a valuable tool for research applications related to autoimmune diseases, with demonstrated efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
