Product Data Sheet
YLIU-4-105-1
Catalog No. A33288
YLIU-4-105-1 is a Type II JAK2 inhibitor that selectively targets the ATP-binding pocket of the JH1 domain. This compound demonstrates significant biological activity, effectively inhibiting phosphorylated STAT5 (pSTAT5) signaling pathways. Research applications include studies on myeloproliferative neoplasms and other diseases associated with JAK2 mutations, with in vivo pharmacodynamic effects such as reduction in spleen-to-body weight ratio and decreased blood reticulocyte counts observed in a dose-dependent manner.
Chemical Information
| Catalog Num | A33288 |
|---|---|
| M. Wt | 605.65 |
| Formula | C32H34F3N7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2417685-83-5 |
| Synonyms | |
| SMILES | O=C(C1=CC(C2=NN3C=C(NC(C4CC4)=O)N=C3C=C2)=C(C)C=C1)NC5=CC(C(F)(F)F)=CC(CN6CCN(CC6)CC)=C5 |
Biological Activity
| Description | YLIU-4-105-1 is a Type II JAK2 inhibitor that selectively targets the ATP-binding pocket of the JH1 domain. This compound demonstrates significant biological activity, effectively inhibiting phosphorylated STAT5 (pSTAT5) signaling pathways. Research applications include studies on myeloproliferative neoplasms and other diseases associated with JAK2 mutations, with in vivo pharmacodynamic effects such as reduction in spleen-to-body weight ratio and decreased blood reticulocyte counts observed in a dose-dependent manner. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
