Product Data Sheet
JAK 3i
Catalog No. A33295
JAK 3i is a highly selective inhibitor of JAK3, exhibiting an IC50 of 0.43 nM. It forms a covalent bond with a specific cysteine residue in the JAK3 kinase domain, demonstrating minimal interaction with JAK1, JAK2, or TYK2. JAK 3i effectively inhibits IL-2-driven T-cell proliferation in vivo, making it a valuable tool for research applications in autoimmune diseases and related therapeutic studies.
Chemical Information
| Catalog Num | A33295 |
|---|---|
| M. Wt | 354.34 |
| Formula | C18H15FN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1918238-72-8 |
| Synonyms | |
| SMILES | CCOC(C1=CN=C2C1=C(C3=C(F)C=CC(NC(C=C)=O)=C3)NC=N2)=O |
Biological Activity
| Description | JAK 3i is a highly selective inhibitor of JAK3, exhibiting an IC50 of 0.43 nM. It forms a covalent bond with a specific cysteine residue in the JAK3 kinase domain, demonstrating minimal interaction with JAK1, JAK2, or TYK2. JAK 3i effectively inhibits IL-2-driven T-cell proliferation in vivo, making it a valuable tool for research applications in autoimmune diseases and related therapeutic studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
