Product Data Sheet
Blovacitinib
Catalog No. A33298
Blovacitinib is a selective inhibitor of Janus kinase 1 (JAK1), demonstrating high potency with IC50 values of 3, 37, 1517, and 36 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This oral agent is primarily utilized in research focused on rheumatoid arthritis, targeting inflammatory pathways associated with this condition. Its specificity for JAK1 makes it an important tool for investigating JAK-STAT signaling mechanisms in various cellular contexts.
Chemical Information
| Catalog Num | A33298 |
|---|---|
| M. Wt | 429.46 |
| Formula | C22H25F2N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2411222-97-2 |
| Synonyms | TUL01101 |
| SMILES | O=C(NC1=NN2C(C=CC=C2C3CCC4(CC3)CN(C4)C([C@@H]5CC5(F)F)=O)=N1)C6CC6 |
Biological Activity
| Description | Blovacitinib is a selective inhibitor of Janus kinase 1 (JAK1), demonstrating high potency with IC50 values of 3, 37, 1517, and 36 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This oral agent is primarily utilized in research focused on rheumatoid arthritis, targeting inflammatory pathways associated with this condition. Its specificity for JAK1 makes it an important tool for investigating JAK-STAT signaling mechanisms in various cellular contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
