Product Data Sheet
Filgotinib-d4
Catalog No. A33316
Filgotinib-d4 is a deuterated form of Filgotinib, a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 10 nM. This isotope-labeled compound retains Filgotinib's high selectivity, demonstrating IC50 values of 28 nM for JAK2, 810 nM for JAK3, and 116 nM for TYK2. Filgotinib-d4 is primarily used in pharmacokinetic studies and isotopic labeling research, facilitating investigations into JAK1-related pathways and therapeutic applications in autoimmune diseases.
Chemical Information
| Catalog Num | A33316 |
|---|---|
| M. Wt | 429.53 |
| Formula | C21H19D4N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2041095-50-3 |
| Synonyms | GLPG0634-d4 |
| SMILES | O=C(C1C([2H])([2H])C1([2H])[2H])NC2=NN3C(C4=CC=C(C=C4)CN5CCS(=O)(CC5)=O)=CC=CC3=N2 |
Biological Activity
| Description | Filgotinib-d4 is a deuterated form of Filgotinib, a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 10 nM. This isotope-labeled compound retains Filgotinib's high selectivity, demonstrating IC50 values of 28 nM for JAK2, 810 nM for JAK3, and 116 nM for TYK2. Filgotinib-d4 is primarily used in pharmacokinetic studies and isotopic labeling research, facilitating investigations into JAK1-related pathways and therapeutic applications in autoimmune diseases. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
