Product Data Sheet
JAK1/TYK2-IN-1
Catalog No. A33320
JAK1/TYK2-IN-1 is a potent dual inhibitor targeting Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), with reported IC50 values of 29 nM and 41 nM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory effects, making it a valuable tool for research related to autoimmune disorders and cytokine signaling pathways. Its ability to selectively inhibit JAK1 and TYK2 enhances its potential for studying the mechanisms of JAK-mediated signaling in various biological contexts.
Chemical Information
| Catalog Num | A33320 |
|---|---|
| M. Wt | 407.39 |
| Formula | C18H20F3N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1883300-48-8 |
| Synonyms | |
| SMILES | O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C |
Biological Activity
| Description | JAK1/TYK2-IN-1 is a potent dual inhibitor targeting Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), with reported IC50 values of 29 nM and 41 nM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory effects, making it a valuable tool for research related to autoimmune disorders and cytokine signaling pathways. Its ability to selectively inhibit JAK1 and TYK2 enhances its potential for studying the mechanisms of JAK-mediated signaling in various biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
