Product Data Sheet
RAI-20
Catalog No. A33322
RAI-20 is a potent orally active dual inhibitor of JAK1 and JAK2, demonstrating IC50 values of 15.1 nM and 22.7 nM, respectively. This compound features favorable pharmacokinetic characteristics, including enhanced plasma stability and extended systemic exposure. In preclinical studies using a collagen-induced arthritis rat model, RAI-20 exhibited significant anti-inflammatory and anti-arthritic effects, effectively decreasing paw swelling volume and overall arthritis index. RAI-20 serves as a valuable tool for investigating the mechanisms underlying rheumatoid arthritis pathology.
Chemical Information
| Catalog Num | A33322 |
|---|---|
| M. Wt | 448.53 |
| Formula | C20H21FN4O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2549180-90-5 |
| Synonyms | H018 |
| SMILES | O=C([C@H]1[C@H](F)C1)NC2=CN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)S4)=CC=CC3=N2 |
Biological Activity
| Description | RAI-20 is a potent orally active dual inhibitor of JAK1 and JAK2, demonstrating IC50 values of 15.1 nM and 22.7 nM, respectively. This compound features favorable pharmacokinetic characteristics, including enhanced plasma stability and extended systemic exposure. In preclinical studies using a collagen-induced arthritis rat model, RAI-20 exhibited significant anti-inflammatory and anti-arthritic effects, effectively decreasing paw swelling volume and overall arthritis index. RAI-20 serves as a valuable tool for investigating the mechanisms underlying rheumatoid arthritis pathology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
