Product Data Sheet
Ritlecitinib (malonate)
Catalog No. A33323
Ritlecitinib (malonate) is a selective, orally bioavailable, irreversible inhibitor of JAK3, exhibiting an IC50 of 33 nM. This compound effectively inactivates JAK3, thereby disrupting signaling pathways and downstream STAT phosphorylation triggered by common gamma chain cytokines, including IL-2 and IL-15. Ritlecitinib (malonate) is particularly useful for research into immune-related conditions, as it diminishes Th1/Th17 cell differentiation and function, and has shown efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis.
Chemical Information
| Catalog Num | A33323 |
|---|---|
| M. Wt | 389.41 |
| Formula | C18H23N5O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2140301-97-7 |
| Synonyms | PF-06651600 (malonate) |
| SMILES | OC(CC(O)=O)=O.C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O |
Biological Activity
| Description | Ritlecitinib (malonate) is a selective, orally bioavailable, irreversible inhibitor of JAK3, exhibiting an IC50 of 33 nM. This compound effectively inactivates JAK3, thereby disrupting signaling pathways and downstream STAT phosphorylation triggered by common gamma chain cytokines, including IL-2 and IL-15. Ritlecitinib (malonate) is particularly useful for research into immune-related conditions, as it diminishes Th1/Th17 cell differentiation and function, and has shown efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
