Product Data Sheet
NVP-BSK805 trihydrochloride
Catalog No. A33324
NVP-BSK805 trihydrochloride is an ATP-competitive inhibitor of Janus kinase 2 (JAK2), exhibiting IC50 values of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. This compound is valuable for studying the roles of JAK family kinases in various biological processes and diseases, including inflammation, hematopoiesis, and cancer. Research applications include preclinical evaluation of therapeutic strategies targeting JAK signaling pathways.
Chemical Information
| Catalog Num | A33324 |
|---|---|
| M. Wt | 599.93 |
| Formula | C27H31Cl3F2N6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2320258-95-3 |
| Synonyms | |
| SMILES | FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.[H]Cl.[H]Cl.[H]Cl |
Biological Activity
| Description | NVP-BSK805 trihydrochloride is an ATP-competitive inhibitor of Janus kinase 2 (JAK2), exhibiting IC50 values of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. This compound is valuable for studying the roles of JAK family kinases in various biological processes and diseases, including inflammation, hematopoiesis, and cancer. Research applications include preclinical evaluation of therapeutic strategies targeting JAK signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
