Product Data Sheet
JAK-2/3-IN-1
Catalog No. A33342
JAK-2/3-IN-1 is a highly selective inhibitor of Janus kinase 2 (JAK-2) and Janus kinase 3 (JAK-3), exhibiting Ki values of less than 250 nM for both isoforms. This compound is relevant for research applications focused on inflammatory diseases and hematological malignancies where JAK signaling plays a crucial role. Its potency and specificity make it suitable for studying the molecular mechanisms of JAK-related pathways and evaluating potential therapeutic strategies.
Chemical Information
| Catalog Num | A33342 |
|---|---|
| M. Wt | 345.78 |
| Formula | C20H12ClN3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1036241-36-7 |
| Synonyms | |
| SMILES | OC1=CC=C(C2=NC3=CC=CC=C3C4=C5C(NC=C25)=NC=C4)C(Cl)=C1 |
Biological Activity
| Description | JAK-2/3-IN-1 is a highly selective inhibitor of Janus kinase 2 (JAK-2) and Janus kinase 3 (JAK-3), exhibiting Ki values of less than 250 nM for both isoforms. This compound is relevant for research applications focused on inflammatory diseases and hematological malignancies where JAK signaling plays a crucial role. Its potency and specificity make it suitable for studying the molecular mechanisms of JAK-related pathways and evaluating potential therapeutic strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
